Table 3.
Univariate and multivariate Cox proportional hazard regression analyses for BCR-free survival in pT3a patients with PSM.
| Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|
| P | HR (95% CI) | P | |
| Age | 0.629 | ||
| Baseline PSA | 0.211 | ||
| Prostate volume | 0.420 | ||
| Diabetes mellitus | 0.479 | ||
| Hypertension | 0.726 | ||
| Body mass index | 0.800 | ||
| pGS | |||
| ≤7 | Ref. | ||
| ≥8 | 0.119 | ||
| Lymphovascular invasion | 0.121 | ||
| EPE width | 0.010 | 1.003 (0.978–1.028) | 0.817 |
| EPE depth | 0.690 | ||
| PSM status | |||
| No. of PSM | |||
| 1 | Ref. | Ref. | Ref. |
| 2 | 0.750 | 1.324 (0.595–2.949) | 0.492 |
| ≥3 | 0.003 | 2.723 (1.256–5.902) | 0.011 |
| mGS | |||
| 3 | Ref. | Ref. | Ref. |
| ≥4 | 0.013 | 2.356 (1.060–5.238) | 0.035 |
| Length of PSM | |||
| <3 mm | Ref. | Ref. | Ref. |
| ≥3 mm | 0.015 | 1.024 (0.994–1.055) | 0.008 |
| Percent tumor volume | 0.815 | ||
| Operation method (open vs. robot) | 0.823 | ||
BCR, biochemical recurrence; CI, confidence interval; HR, hazard ratio; PSM, positive surgical margin; PSA, prostate-specific antigen; pGS, pathologic Gleason score; EPE, extraprostatic extension; mGS, margin Gleason score.