Table 3.
Univariate and multivariate analysis for development of grade ≥3 toxicity
| Univariate |
Multivariate |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Level | HR | 95% CI | P value | Variable | HR | 95% CI | P value | |
| Age | 1.05 | 1.003-1.10 | .037 | Age | 1.05 | 0.96-1.14 | .29 | ||
| ECOG | 1-3 vs 0 | 0.79 | .31-2.04 | 0.63 | |||||
| Size, cm | 1.23 | .81-1.86 | 0.34 | ||||||
| T stage | T3/T4 vs T1/T2 | 0.77 | .32-1.89 | 0.57 | |||||
| N stage | N+ vs N0 | 0.98 | .39-2.45 | 0.97 | |||||
| Dose, GyE | 0.97 | 0.88-1.07 | .57 | ||||||
| Modality | PBS vs PS | 1.03 | .42-2.54 | 0.95 | |||||
| Location | GEJ vs other | 0.074 | .016-.34 | 0.0009 | Location | 0.10 | .02-.48 | 0.004 | |
| Mean heart dose | 0.81 | 0.62-1.05 | .11 | ||||||
| Mean lung dose | 0.78 | 0.45-1.33 | .36 | ||||||
| Mean liver dose | 1.1 | 0.89-1.35 | .38 | ||||||
| Maximum cord dose | 1.27 | 0.95-1.70 | .11 | ||||||
Abbreviations: CI = confidence interval; ECOG = Eastern Cooperative Oncology Group; GEJ = gastroesophageal junction; HR = hazard ratio; PBS = pencil beam scanning; PS = passive scattering.