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. 2021 Oct 8;195:105185. doi: 10.1016/j.antiviral.2021.105185

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© 2021 Published by Elsevier B.V.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Kinetic interaction between anti-SARS-CoV-2 Spike mAbs and variant spike protein, neutralization abilities of convalescent plasma and anti-SARS-CoV-2 spike mAbs against SARS-CoV-2 strains B.1.351, D614, and D614G. (a) Binding responses of anti-SARS-CoV-2 S protein mAbs, S1D2-hIgG1, STI-1499-LALA and 1741-LALA to the S1 fragment of the S protein from SARS-CoV-2 variants, including 2019-nCoV, B.1.1.7 (HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H)-, B.1.351 (K417N, E484K, N501Y, D614G)-, and B.1.617.2 (T19R, G142D, E156G, 157–158 deletion, L452R, T478K, D614G, P681R)- lineage. (b) Panels indicate the association and dissociation of 1741-LALA at various concentrations binding to S1 of 2019-nCoV, B.1.1.7, B.1.351 and B.1.617.2 lineage. The table shows the association rate (ka), dissociation rate (kd), and dissociation constant (K_D). Neutralization titers of (c) convalescent plasma from three different COVID-19 patients against SARS-CoV-2 D614 and PRNT₅₀ curves of anti-SARS-CoV-2 spike mAbs against (d) D614 (e) D614G, and (f) B.1.351. Tables indicate the titers of each plasma sample or mAb concentrations in neutralizing 50% of input virus.