Figure 3.

Comparison of PTM frequencies between different groups on human proteome

A. Venn diagram displaying the overlap of phase-separating proteins with different PTM types. The PTM datasets were collected from the PhosphoSitePlus database. B. For all PTM types, frequencies for proteins in set P are significantly higher than those for set N. P values are calculated through the two-sided Mann–Whitney U test. C. Distribution of IDR contents of proteins in set P and set N. Most proteins in set N have low proportions of IDRs. D. Set N was resampled into a subset according to IDR content distribution of set P. P value indicates that IDR contents of proteins in sampled set N have a similar distribution with that in set P. E. PTM frequencies of proteins in set P are still higher than those in resampled set N.