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Synthesis of griseofulvin‐derived fragments to be used in iso‐oxa‐PS reactions. a) 1. griseofulvin 4 (1 equiv.), Pd/C (10% w/w), H2, EtOAc, 22 °C, 54 h, 2. 2 m H2SO4, AcOH, 80 °C, 16 h, 3. Pd/C (10% w/w), H2, EtOAc, 22 °C, 6 h, b) MgI2 (1 equiv.), Et2O/toluene, 80 °C, 20 h, c) alkyl bromide (1.05 equiv.), K2CO3 (2.5 equiv.), DMF, 65 °C, 3 h, d) boronic acid (1 equiv.), Pd(OAc)2 (3 mol%), XPhos (6 mol%), K3PO4 (2 equiv.), THF, 80 °C, 24 h.
