Table 3.
Effect of various risk factors for persistent seizures at 2 y of age
| Characteristics | Continuing seizures (%) | Cessation (%) | p value |
|---|---|---|---|
| Age at onset of spasms | |||
| ≤ 4 mo | 28 (38.9) | 14 (33.3) | 0.55 |
| > 4 mo | 44 (61.1) | 28 (66.6) | |
| Lead time to treatment | |||
| > 1 mo | 63 (87.5) | 38 (90.5) | 0.44 |
| ≤ 1 mo | 9 (12.5) | 4 (9.5) | |
| Response to standard therapy* | |||
| No response | 43 (60) | 9 (22) | < 0.001 |
| Complete cessation | 29 (40) | 33 (78) | OR (95% CI) 5.4 (2.3–13) |
| Etiology | |||
| Structural | 63 (87.5) | 28 (66.7) | 0.008 |
| Nonstructural | 9 (12.5) | 14 (33.3) | OR (95% CI) 3.5 (1.4–9) |
*Response to standard therapy was defined as clinical cessation of spasms with 14 d of initiation of standard therapy, lasting for ≥ 28 d
CI Confidence interval, OR Odds ratio