Table 4.
Predictors of neurodevelopmental outcomes in children with West syndrome aged more than 2 y (social quotient based on Vineland Social Maturity Scale)
| Characteristics | SQ > 55 (%) | SQ < 55 (%) | p value |
|---|---|---|---|
| Age at onset of spasms | |||
| ≤ 4 mo | 6 (22) | 36 (41) | 0.055 |
| > 4 mo | 21 (78) | 51 (59) | OR (95% CI): 2.5 (0.9–6.7) |
| Treatment lag | |||
| > 1 mo | 24 (88.9) | 77 (88.5) | 0.63 |
| ≤ 1 mo | 3 (11.1) | 10 (11.5) | |
| Response to standard therapy* | |||
| No response | 5 (19) | 47 (54) | < 0.001 |
| Complete cessation | 22 (81) | 40 (46) | OR (95% CI): 5.2 (1.8–14.9) |
| Etiology | |||
| Structural | 17 (63) | 74 (85) | 0.016 |
| Nonstructural | 10 (37) | 13 (15) | OR (95% CI): 3.3 (1.3–8.9) |
*Response to standard therapy was defined as clinical cessation of spasms with 14 d of initiation of standard therapy, lasting for ≥ 28 d
CI Confidence interval, OR Odds ratio, SQ Social quotient