Table 3.
Association of klotho with prevalent hypertension and number of BP medications (n=2785)
| Model 1 | Model 2 | Model 3 | Model 4 | ||
| Prevalent Hypertension | n with Prevalent Hypertension | Odds Ratio (95% Confidence Interval) | Odds Ratio (95% Confidence Interval) | Odds Ratio (95% Confidence Interval) | Odds Ratio (95% Confidence Interval) |
| Klotho (per doubling) | 2093 | 1.04 (0.90 to 1.19) | 1.00 (0.87 to 1.15) | 1.02 (0.88 to 1.19) | 1.04 (0.89 to 1.21) |
| Klotho quartiles | |||||
| <478 | 516 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 478–630 | 532 | 1.14 (0.89 to 1.46) | 1.18 (0.92 to 1.51) | 1.18 (0.91 to 1.53) | 1.20 (0.92 to 1.56) |
| 631–816 | 516 | 1.00 (0.79 to 1.28) | 1.00 (0.78 to 1.27) | 1.01 (0.79 to 1.31) | 1.01 (0.78 to 1.31) |
| >816 | 529 | 1.12 (0.88 to 1.43) | 1.03 (0.80 to 1.32) | 1.07 (0.82 to 1.40) | 1.11 (0.85 to 1.45) |
| Baseline BP meds | Median n of meds | RR (95% CI) | RR (95% CI) | RR (95% CI) | RR (95% CI) |
| Klotho (per doubling) | 1 | 0.93 (0.88 to 0.99) | 0.93 (0.87 to 0.98) | 0.95 (0.90 to 1.01) | 0.96 (0.91 to 1.02) |
| Klotho quartiles | |||||
| <478 | 1 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 478–630 | 1 | 0.91 (0.82 to 1.02) | 0.93 (0.84 to 1.04) | 0.95 (0.86 to 1.06) | 0.96 (0.87 to 1.07) |
| 631–816 | 1 | 0.88 (0.79 to 0.98) | 0.89 (0.79 to 0.99) | 0.91 (0.82 to 1.01) | 0.92 (0.83 to 1.03) |
| >816 | 1 | 0.88 (0.79 to 0.99) | 0.87 (0.78 to 0.97) | 0.91 (0.82 to 1.02) | 0.92 (0.83 to 1.03) |
Model 1 unadjusted analysis. Model 2 adjusted for age, sex, and race. Model 3 model 2+diabetes, cardiovascular disease, GFR, UACR, BMI, and smoking. Model 4 model 3+calcium, phosphate, 25(OH) vitamin D, PTH, and FGF-23. RR, rate ratio, equivalent to count ratio; 95% CI, 95% confidence interval; UACR, urine albumin-creatinine ratio; BMI, body mass index; PTH, parathyroid hormone; FGF-23, fibroblast growth factor 23.