Table 4.

Association of klotho with incident hypertension during follow-up

			Incidence Rate	Model 1	Model 2	Model 3	Model 4
Klotho	n	n with Incident Hypertension	(%/yr)	Hazard Ratio (95% Confidence Interval)	Hazard Ratio (95% Confidence Interval)	Hazard Ratio (95% Confidence Interval)	Hazard Ratio (95% Confidence Interval)
Klotho (per doubling)	681	476	14.64	0.82 (0.71 to 0.95)	0.81 (0.70 to 0.94)	0.80 (0.69 to 0.93)	0.80 (0.69 to 0.93)
Klotho quartiles
<478	178	139	18.03	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
478–630	161	103	12.97	0.74 (0.57 to 0.95)	0.74 (0.57 to 0.95)	0.74 (0.57 to 0.96)	0.75 (0.58 to 0.97)
631–816	178	130	15.32	0.87 (0.68 to 1.10)	0.86 (0.68 to 1.10)	0.87 (0.69 to 1.11)	0.85 (0.67 to 1.08)
>816	164	104	12.39	0.72 (0.56 to 0.93)	0.72 (0.55 to 0.93)	0.72 (0.55 to 0.93)	0.72 (0.55 to 0.93)

Model 1 unadjusted analysis. Model 2 adjusted for age, sex, and race. Model 3 model 2+diabetes, cardiovascular disease, eGFR UACR, BMI, and smoking. Model 4 model 3+calcium, phosphate, 25(OH) vitamin D, PTH, and FGF-23. UACR, urine albumin-creatinine ratio; BMI, body mass index; PTH, parathyroid hormone; FGF-23, fibroblast growth factor 23.