Table 5.
Association of klotho with systolic and diastolic BP trajectories
| Annualized Absolute Change in Systolic BP | |||||
| Model 1 | Model 2 | Model 3 | Model 4 | ||
| Klotho | N | β (95% Confidence Interval) | β (95% Confidence Interval) | β (95% Confidence Interval) | β (95% Confidence Interval) |
| Klotho (per doubling) | 2774 | −0.18 (−0.33 to −0.04) | −0.19 (−0.33 to −0.04) | −0.16 (−0.31 to −0.02) | −0.16 (−0.31 to −0.01) |
| Klotho quartiles | |||||
| <478 | 694 | 0 (ref) | 0 (ref) | 0 (ref) | 0 (ref) |
| 478–630 | 693 | −0.35 (−0.61 to −0.09) | −0.31 (−0.57 to −0.05) | −0.31 (−0.57 to −0.05) | −0.30 (−0.56 to −0.04) |
| 631–816 | 694 | −0.34 (−0.59 to −0.08) | −0.33 (−0.58 to −0.08) | −0.32 (−0.58 to −0.07) | −0.31 (−0.56 to −0.05) |
| >816 | 693 | −0.33 (−0.58 to −0.07) | −0.32 (−0.57 to −0.06) | −0.28 (−0.54 to −0.02) | −0.27 (−0.53 to −0.01) |
| Annualized Absolute Change in Diastolic BP | |||||
| Model 1 | Model 2 | Model 3 | Model 4 | ||
| Klotho (per doubling) | 2774 | −0.09 (−0.17 to −0.02) | −0.09 (−0.17 to −0.02) | −0.10 (−0.18 to −0.03) | −0.10 (−0.18 to −0.02) |
| Klotho quartiles | |||||
| <478 | 694 | 0 (ref) | 0 (ref) | 0 (ref) | 0 (ref) |
| 478–630 | 693 | −0.16 (−0.29 to −0.02) | −0.15 (−0.29 to −0.02) | −0.15 (−0.29 to −0.02) | −0.15 (−0.29 to −0.02) |
| 631–816 | 694 | −0.21 (−0.34 to −0.07) | −0.20 (−0.34 to −0.07) | −0.21 (−0.35 to −0.08) | −0.21 (−0.34 to −0.07) |
| >816 | 693 | −0.18 (−0.32 to −0.05) | −0.18 (−0.31 to −0.04) | −0.19 (−0.33 to −0.06) | −0.19 (−0.32 to −0.05) |
Model 1 unadjusted analysis. Model 2 adjusted for age, sex, and race. Model 3 model 2+diabetes, cardiovascular disease, eGFR, UACR, BMI, and smoking. Model 4 model 3+calcium, phosphate, 25(OH) vitamin D, PTH, and FGF-23. UACR, urine albumin-creatinine ratio; BMI, body mass index; PTH, parathyroid hormone; FGF-23, fibroblast growth factor 23.