Table 1.

Treatment modification for potassium, eGFR, and sodium levels

Result	Action
Potassium (mEq/L)
Participants on chlorthalidone
>3.5	No action
3.0–3.5	Remeasure serum potassium in 2 wk. Dietary advice
<3.0	Stop drug
Participants on spironolactone
5.5–5.9	Reduce to alternate days
6.0–6.5	Stop for 1 wk and recommence on alternate day if potassium <5 mEq/L on repeat check
>6.5	Stop trial drug
eGFR reduction (%)
<25	No action
25–30	Stop trial drug and restart after 1 wk on alternate days
>30	Stop trial drug
Sodium (mmol/L)
>135	No action
135–130	Remeasure serum sodium in 2 wk
<125	Stop trial drug