TABLE 2.
FPS induced by various concentrations of perforin and PLO in Jurkat cells compared with concentrations producing minimal or near-maximal Cr release
| Lysin | Concn (U/ml) | FPSa (kDa) | Minimum concn producing >80% specific 51Cr release2 (U/ml) | Minimum proapoptotic concn (U/ml) |
|---|---|---|---|---|
| Perforin | 130 | |||
| 200 | <8 | |||
| 400 | <8 | |||
| 1,000 | ||||
| 800 | <8 | |||
| 1,600 | <8 | |||
| 4,000 | >27 | |||
| 5,000 | >67 | |||
| PLO | 2 | <8 | ||
| 5 | ||||
| 6 | <8 | |||
| 160 | ||||
| 160 | <9 | |||
| 800 | >67 |
a
See Results for definition.
b
As indicated in Table 1, and interpolated into the FPS data above, for purposes of comparison.