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. 2021 Oct 7;9(1):e002394. doi: 10.1136/bmjdrc-2021-002394

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Granule attachment and fusion after beta cell desensitization or rest. (A) All granules that were present in the submembrane space for more than 1 s were subdivided into five groups with increasing periods of residence. The effects of treatment (tolbutamide or clonidine) and of time period were highly significant (p˂0.001, two-way analysis of variance (ANOVA)). Values are means±SEM of 52 (tolbutamide and controls) or 60 (clonidine and controls) cells each. (B) Diminished granule fusions after desensitization by tolbutamide (orange symbols, upper graph) but increased fusions after rest by clonidine (blue symbols, lower graph). The effect of treatment was highly significant in both cases (p˂0.001), whereas the effect of time was only significant for clonidine (p˂0.01, two-way ANOVA). Values are means±SEM of 17 (tolbutamide) or 14 (control) cells from six experiments each and of 13 (clonidine) or 15 (control) cells from six experiments each.