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. 2021 Oct 7;12:527. doi: 10.1186/s13287-021-02595-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Potential strategies for overcoming the issue of prolonged CAR-T persistence which leads to T-cell aplasia. A Selective elimination of the administered CAR-Ts that is achievable through equipping the CAR-Ts with different safety switches. B Transient CAR expression that can be achieved through the mRNA electroporation of the isolated T cells. CAR chimeric antigen receptor; FcγR Fcγ receptor; G ganciclovir; G-Mp ganciclovir-monophosphate; G-Tp ganciclovir-triphosphate; HSV-TK Herpes simplex virus thymidine kinase; iCasp inducible caspase; mAb monoclonal antibody