Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 7;52:128. doi: 10.1186/s13567-021-00993-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

The host range of CWD prions. CWD prions circulate in the Cervidae reservoir (free-ranging and captive or semi-captive animals). While CWD prion strain diversity extend in the Cervidae reservoir is unknown, the strains identified so far in the North-American and European reservoirs are different. North-American CWD prions are able to propagate naturally (grey arrow) or experimentally (blue arrows) in many different species. The impact of intermediate hosts replication on the evolution and zoonotic potential of CWD prions is unknown. Many laboratory species have been experimentally infected with CWD prions, including hamsters, bank voles, transgenic mice expressing ovine or pig PrP and squirrel monkeys. CWD zoonotic threats to humans remain unclear.