Table 1.

Power of the different methods depending on the number of components in the ‘Random LD Simulations’ (dilution effect)

Size	Model	Method	Significance	1	2	3	4	5	6–10	11–15	16–20	> 20
1000	MD	WS	$1\times {10}^{-5}$	0.4	0.5	0.8	1.0	1	0.7	0.6	0.7	0.7
1000	RD	WS	$1\times {10}^{-5}$	0.8	0.1	0.0	0.3	0.2	0.5	0.9	0.2	0.4
1000	NA	SKAT	$1\times {10}^{-5}$	0.0	0.0	0.0	0.0	0.0	0.1	0.2	0.8	1.8
1000	NA	GWAS	$5\times {10}^{-8}$	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
5000	MD	WS	$1\times {10}^{-5}$	9.2	11.1	9.1	6.1	4.6	3.5	2.5	2.3	2.3
5000	RD	WS	$1\times {10}^{-5}$	9.6	9.3	7.3	5.4	5.1	2.6	1.4	1.7	1.6
5000	NA	SKAT	$1\times {10}^{-5}$	0.0	0.2	0.57	0.8	2.8	7.14	26.2	54.5	82.0
5000	NA	GWAS	$5\times {10}^{-8}$	45.5	25.8	16	3.1	2.7	2.8	1.1	0.6	0.3
10,000	MD	WS	$1\times {10}^{-5}$	48.1	46.5	44.4	45.1	44.1	31.0	24.6	21.2	21.2
10,000	RD	WS	$1\times {10}^{-5}$	49.1	45.2	46.3	47.2	39.2	27.2	15.6	17.2	15.9
10,000	NA	SKAT	$1\times {10}^{-5}$	0.2	1.1	1.3	4.4	7.3	32.0	71.6	92.8	99.2
10,000	NA	GWAS	$5\times {10}^{-8}$	100	81.8	75.0	68.8	30.6	28.1	15.5	9.6	3.3