Table 2.

Power of the different methods depending on the number of components in the ‘High LD Simulations’ (dilution effect)

Size	Model	Method	Significance	1	2	3	4	5	6–10	11–15	16–20	> 20
1000	MD	WS	$1\times {10}^{-5}$	0.9	1.1	0.7	0.9	0.6	0.8	0.6	0.9	0.9
1000	RD	WS	$1\times {10}^{-5}$	1.2	0.9	0.2	0.7	0.8	0.5	0.6	0.4	0.8
1000	NA	SKAT	$1\times {10}^{-5}$	0.0	0.0	0.0	0.0	0.0	0.1	1.4	4.6	19.8
1000	NA	GWAS	$5\times {10}^{-8}$	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
5000	MD	WS	$1\times {10}^{-5}$	17.3	18.3	19.1	20.6	24.0	20.9	19.4	19.3	20.2
5000	RD	WS	$1\times {10}^{-5}$	7.3	10.5	8.8	7.1	9.4	8.5	9.2	8.0	9.3
5000	NA	SKAT	$1\times {10}^{-5}$	0.0	0.2	1.4	3.0	5.9	26.7	69.5	95.4	99.9
5000	NA	GWAS	$5\times {10}^{-8}$	45.5	25.8	16	3.1	2.7	2.8	1.1	0.6	0.4
10,000	MD	WS	$1\times {10}^{-5}$	54.8	70.9.	86.8	90.1	92.2	95.4	93.6	94.1	96.5
10,000	RD	WS	$1\times {10}^{-5}$	57.3	49.8	54.6	53.8	56.1	54.4	50.7	50.6	52.1
1000	NA	SKAT	$1\times {10}^{-5}$	0.0	1.1	6.5	15.6	24.9	64.5	96.5	100.0	100.00
10,000	NA	GWAS	$5\times {10}^{-8}$	100	81.8	75.0	68.8	30.6	28.1	15.5	9.6	3.2

MD, mono-directional model; RD, random directional model; NA, not applicable