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. 2021 Oct 7;22:67. doi: 10.1186/s12865-021-00459-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The influence of TLR2 activation on cytotoxic pathways of peripheral and tumor-infiltrating CD8⁺ T cells from NC and GC patients. CD8⁺ T cells were purified from peripheral bloods of NC (n = 9) and GC patients (n = 11), as well as from tumor residency of GC patients (n = 11). 2.5 × 10⁴ of CD8⁺ T cells were cultured for 12 h in the presence of anti-CD3/CD28 with or without TLR2 agonist Pam3Csk4. mRNA relative level corresponding to a perforin, b granzyme B, and c FasL in CD8⁺ T cells with or without PamCsk4 stimulation was semi-quantified by real-time PCR. The secretion of d perforin and e granzyme B by CD8⁺ T cells was analyzed by ELISPOT. The columns indicated means, and the bars indicated standard deviation. Significances were determined by LSD-t test or paired t test