Table 3.
Cytokine production in direct contact coculture system response to TLR2 activation (pg/ml)
NC (peripheral) (n = 6) | GC (peripheral) (n = 17) | GC (tumor-infiltrating) (n = 17) | ||||
---|---|---|---|---|---|---|
− Pam3Csk4 | + Pam3Csk4 | − Pam3Csk4 | + Pam3Csk4 | − Pam3Csk4 | + Pam3Csk4 | |
IFN-γ | 1722 ± 582.7 | 1810 ± 430.8 | 1182 ± 297.2# | 1019 ± 381.1 | 971.6 ± 101.8 # | 1001 ± 342.6 |
TNF-α | 553.1 ± 174.5 | 549.7 ± 161.9 | 391.4 ± 87.14# | 378.0 ± 92.44 | 360.5 ± 77.25# | 371.2 ± 82.41 |
IL-2 | 221.8 ± 51.04 | 241.2 ± 48.16 | 168.4 ± 32.45# | 157.9 ± 47.79 | 178.0 ± 45.18# | 172.9 ± 34.50 |
IL-6 | 109.2 ± 23.48 | 105.4 ± 38.02 | 71.03 ± 16.46# | 77.10 ± 19.24 | 71.42 ± 17.98# | 67.14 ± 10.57 |
IL-8 | 358.0 ± 100.2 | 335.1 ± 109.4 | 234.4 ± 87.01# | 221.9 ± 57.02 | 228.1 ± 71.03# | 231.4 ± 66.02 |
#P < 0.05 compared with NC