Table 2.
Initial Clinical Progression
| Baseline Ordinal Score | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Overall | Room Air [4] | Supplemental Oxygen [5] | Noninvasive Ventilation/ High-flow Oxygen [6] | Invasive Ventilation [7] | ||||||
| Remdesivir | Placebo | Remdesivir | Placebo | Remdesivir | Placebo | Remdesivir | Placebo | Remdesivir | Placebo | |
| (N = 533) | (N = 518) | (N = 75) | (N = 63) | (N = 232) | (N = 203) | (N = 95) | (N = 98) | (N = 131) | (N = 154) | |
| First transition | ||||||||||
| Improvement | 374 (70%) | 323 (62%) | 52 (69%) | 38 (60%) | 170 (73%) | 124 (61%) | 61 (64%) | 58 (59%) | 91 (69%) | 103 (67%) |
| Deterioration | 133 (25%) | 166 (32%) | 23 (31%) | 25 (40%) | 58 (25%) | 75 (37%) | 30 (32%) | 40 (41%) | 22 (17%) | 26 (17%) |
| No change | 26 (5%) | 29 (6%) | 0 (0%) | 0 (0%) | 4 (2%) | 4 (2%) | 4 (4%) | 0 (0%) | 18 (14%) | 25 (16%) |
| First 2 transitions | ||||||||||
| Sustained improvement or recovery | 325 (61%) | 264 (51%) | 52 (69%) | 38 (60%) | 157 (68%) | 107 (53%) | 44 (46%) | 46 (47%) | 72 (55%) | 73 (47%) |
| Transient improvement | 49 (9%) | 59 (11%) | Not applicable | 13 (6%) | 17 (8%) | 17 (18%) | 12 (12%) | 19 (15%) | 30 (19%) | |
| Transient deterioration | 80 (15%) | 81 (16%) | 20 (27%) | 18 (29%) | 46 (20%) | 40 (20%) | 14 (15%) | 23 (23%) | Not applicable | |
| Sustained deterioration or death | 53 (10%) | 85 (16%) | 3 (4%) | 7 (11%) | 12 (5%) | 35 (17%) | 16 (17%) | 17 (17%) | 22 (17%) | 26 (17%) |
Summary of patients’ first ordinal score transition and first two transitions. For the first transition, “improvement” (“deterioration”) is defined as being in a better (worse) ordinal score than baseline. For the first two transitions, “sustained improvement or recovery” is defined as having a first transition in the direction of improvement on the ordinal score followed by either no change or a second transition in the direction of improvement (which for some patients indicates recovery); “transient improvement” is defined as having a first transition in the direction of improvement followed by a second transition in the direction of deterioration; “transient deterioration” is defined as having a first transition in the direction of deterioration followed by a second transition in the direction of improvement; and “sustained deterioration or death” is defined as having a first transition in the direction of deterioration followed by either no change or a second transition in the direction of deterioration (which for some patients indicates death).