Comparison 5. N‐acetylcysteine versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
5.1 Response rate	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1.1 At 3 months	2	69	Odds Ratio (M‐H, Fixed, 95% CI)	0.82 [0.32, 2.14]
5.2 Adverse events: Young Mania Rating Scale	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.2.1 2 weeks	1	80	Mean Difference (IV, Fixed, 95% CI)	‐0.90 [‐1.11, ‐0.69]
5.2.2 3 months	2	121	Mean Difference (IV, Fixed, 95% CI)	‐0.84 [‐1.08, ‐0.60]
5.3 Depression rating scale score change	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.3.1 at 3 months	2	58	Mean Difference (IV, Fixed, 95% CI)	1.28 [0.24, 2.31]
5.4 Suicidality rating scale	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only