ISRCTN14689382.

Study name	Ketamine augmentation of ECT to improve outcomes in depression
Methods	Parallel RCT
Participants	Current DHRSD: SM‐IV diagnosis of a major depressive episode, moderate or severe as part of unipolar or bipolar disorder mood disorder 18+ years old Verbal IQ more than or equal to 85
Interventions	Ketamine hydrochloride injection vs saline solution
Outcomes	HVLT‐R, AMI‐SD, COWAT MVG complex figure, GSE‐My MADRS more than or equal to 10 Number of ECT treatments to achieve response (50% MADRS decrease from baseline) CGI‐S, CGI‐I
Starting date	1/5/2012
Contact information	ian.anderson@manchester.ac.uk
Notes	Ongoing