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. 2021 Aug 23:bbab325. doi: 10.1093/bib/bbab325

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© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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The unique GRNs of DETFs from the patients with severe COVID-19. A. GRNs related to response to a decreased oxygen level (GO:0036293); DNA damage response (GO:0030330); negative regulation of the mitotic cell cycle (GO:0045930); and the intrinsic apoptotic signaling pathway (GO:0097193). B. GRNs related to the microtubule organizing center (GO:0005851). The edges are shown if their absolute Pearson correlation coefficients are larger than 0.4. DETFs: differentially expressed transcription factors.