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. 2021 Aug 31:aqab092. doi: 10.1093/ajcp/aqab092

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© American Society for Clinical Pathology, 2021. All rights reserved.For permissions, please e-mail: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Healthy donor range of spike protein antibody (S-Ab) concentrations postvaccination. S-Ab concentrations were measured in 11 healthy donors approximately 3 weeks after administration of the first dose of the Pfizer/BioNTech mRNA COVID-19 vaccine and in 37 healthy donors between 2 and 5 weeks after administration of the second dose of the Pfizer/BioNTech vaccine. All donors received both doses of the Pfizer/BioNTech vaccine and within the recommended timeframe. The median of the first group was 42.23 U/mL, while the median of the second group was 1,482 U/mL. Using the Mann-Whitney U test, the difference in median S-Ab concentrations measured for the 2 groups was statistically significant (* P < .0001).