Table 1.

Amino acid variants with significantly positive fitness effects in the pre-2020-09 data.

Variant	MLE	95% CI	Frequency
nsp2 A336V	1.15	1.13–1.22	0.006
nsp2 G199E	1.223	1.13–1.26	0.005
nsp3 K384N	1.068	1.06–1.12	0.015
nsp13 P47L	1.113	1.01–1.13	0.006
S Q675R	1.17	1.14–1.22	0.005
ORF9 S194L	1.13	1.01–1.24	0.048
ORF9 T205I	1.177	1.05–1.24	0.007