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. 2021 Oct 5;117(14):2807–2820. doi: 10.1093/cvr/cvab308

Figure 1.

Figure 1

Prognostic value of haematological parameters in COVID-19 patients at admission and development of CAC and thromboinflammation. (A) Total number of patients per age group and incidence of uncomplicated hospitalization, requirement of ICU, and mortality. (B) Total number of patients and incidence of uncomplicated hospitalization, requirement of ICU, and mortality according to COVID-19 classification at admission. (C) Death probability for each patient estimated by logistic regression with the predictors age, age + D-dimer, age + prothrombin time (PT), age + INR, age + aPTT. Prognostic potential was compared using receiver operating characteristic curve analyses. (D–F) Time courses of D-dimer (D), citrullinated histone 3 (H3Cit)–DNA complexes (E), and cell-free DNA (cfDNA) (F) are shown for patients with uncomplicated course of disease (green), those who were admitted to an ICU (yellow), and those who died (red). Time courses were modelled using mixed linear models, leading to respective P-values for comparison of dynamics over time between outcome cohorts. Lines with dotted error bands represent least-squared means of log-transformed D-dimer values with 95% confidence intervals (N = 586 in A–D, N = 106 in E and F, *P < 0.05, **P < 0.001).