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. 2021 Sep 14;14:712609. doi: 10.3389/fnmol.2021.712609

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Copyright © 2021 Mahadevan, Mitra, Zhang, Yuan, Peltekian, Chittajallu, Esnault, Maric, Rhodes, Pelkey, Dale, Petros and McBain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression of interneuron marker genes across subtypes upon Grin1-ablation. (A) Heatmap of log2 FC of significant DEGs in neocortical and hippocampal MGE cardinal subtypes, showing notable MGE marker genes. Representative box-violin plots of top differentially expressed genes from the above that represent (Bi), a misexpression unique to a single MGE-interneuron subtype in the Grin1^fl/fl (Bii), a misexpression across all MGE-derived interneuron subtypes in the Grin1^fl/fl; (Biii), a misexpression between MGE-derived interneuron subtypes in the Grin1^fl/fl. (C) MGE-Ribotag-seq normalized reads, cross-validating the misexpressed interneuron marker genes in neocortex and hippocampus.