Table 1.
Genomic mutations linked to the suppression of abo1∆ cells growth defect.
| Suppressor strains | Single-nucleotide variant | Amino acid modification | Protein name | Function (protein complex) |
|---|---|---|---|---|
| abo1∆_supA | G>A (3778764) | R1303stop | Hip3 | HIRA complex |
| abo1∆_supB | G>A (3780744) | Q643stop | ||
| abo1∆_supC | A>C (3779930) | L914stop | ||
| abo1∆_supD | T>A (3780930) | K581stop | ||
| abo1∆_supE | A>T (3780247) | C808stop | ||
| abo1∆_supF | ins T (3782449) | N74fs | ||
| abo1∆_supG | G>T (3016457) | G307A | Slm9 | |
| abo1∆_supH | C>T (3017455) | Q640stop | ||
| abo1∆_supI | ins A (2539317) | I213fs | Pcf1 | CAF1 complex |
| abo1∆_supJ | T>C (1365405) | L83S | Hht2 (H3) | Histones |
| abo1∆_supK | T>G (4699234) | T55P | Hhf1 (H4) |
Detailed description of the single-nucleotide variants in genes encoding subunits of HIRA and CAF1 histone chaperone complexes or histone H3 and H4 found in the 11 abo1∆_sup (A to K) clones (also see Fig S3). The genomic positions of the single-nucleotide variants are indicated in brackets. >, substitution; ins, insertion; fs, frameshift; stop, non-sense.