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Calculated pKa values of potent ligands.
| Ligands | Breakdown | pKa | Nature |
|---|---|---|---|
| L1 | Naphthol | 14.59 | |
| Tertiary amine | 15.59 | Basic | |
| Carbonyl (amide) | 13.95 | ||
| L2 | Carbonyl | −0.70 | |
| Tertiary amine | 15.58 | ||
| Naphthol | 14.58 | Basic | |
| Carbonyl (amide) | 13.94 | ||
| Amide (NH2) | −1.36 | ||
| L6 | Carbonyl | −0.66 | Basic |
| =NH (carbamimidoyl) | 12.78 | ||
| Nafamostat | =NH (carbamimidoyl) | 12.81 | Basic |
| Amino | 11.65 |
