TABLE 2.
Annual All-cause Health Care Resource Utilization Among Patients With NAFLD/NASH by Liver Disease Severity Stage
| NAFLD/NASH Without AdvLD (N=453,564) | NAFLD/NASH§ (N=468,017) | CC (N=7665) | DCC (N=15,883) | LT (N=696) | HCC (N=428) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Health Care Resource Utilization Parameters | Preindex | Postindex | Preindex | Postindex | Preindex | Postindex | Preindex | Postindex | Preindex | Postindex | Preindex | Postindex |
| Inpatient hospitalizations | ||||||||||||
| Patients with hospitalization [n (%)] | 22,331 (4.9) | 39,351 (8.7) | 23,972 (5.1) | 42,179 (9.0) | 726 (9.5) | 1008 (13.2)† | 5053 (31.9) | 8174 (51.6)†‡ | 320 (46.0) | 549 (78.9)†‡ | 78 (18.2) | 107 (25.0)†‡ |
| Annual admissions per patient [mean (SD)] | 0.12 (0.57) | 0.24 (0.93)* | 0.12 (0.59) | 0.25 (0.95)* | 0.24 (0.83) | 0.38 (1.28)*† | 0.94 (1.74) | 2.25 (3.51)*†‡ | 1.63 (2.44) | 3.11 (3.33)*†‡ | 0.55 (1.60) | 1.25 (3.08)*†‡ |
| % change from preindex to postindex period | 103.6 | 102.2 | 61.8 | 140.2 | 128.7 | 90.4 | ||||||
| Length of stay [mean (SD)] | 0.70 (0.57) | 0.81 (1.00)* | 0.71 (0.59) | 0.82 (1.01)* | 0.73 (0.58) | 0.89 (1.14)† | 1.05 (0.93) | 2.34 (4.00)*†‡ | 1.18 (1.02) | 2.48 (3.75)*†‡ | 0.95 (0.60) | 2.59 (4.46)*†‡ |
| Outpatient services | ||||||||||||
| Patients with service [n (%)] | 433,586 (95.6) | 453,298 (99.9) | 447,760 (95.7) | 467,745 (99.9) | 7599 (99.1) | 7651 (99.8)† | 15,653 (98.9) | 15,791 (99.7)† | 689 (99.0) | 695 (99.9) | 425 (99.3) | 428 (100.0) |
| Annual services per patient [mean (SD)] | 25.9 (24.1) | 30.7 (27.7)* | 26.4 (24.8) | 31.2 (28.3)* | 39.1 (29.5) | 38.9 (31.8)† | 53.1 (47.0) | 68.0 (58.3)*†‡ | 69.2 (54.1) | 75.6 (61.4)*†‡ | 51.1 (43.4) | 78.1 (68.4)*†‡ |
| % change from preindex to postindex period | 18.4 | 18.1 | -0.5 | 28.0 | 9.3 | 52.8 | ||||||
| Prescription fills | ||||||||||||
| Patients with fills [n (%)] | 388,476 (85.6) | 394,423 (87.0) | 401,776 (85.8) | 407,796 (87.1) | 6962 (90.8) | 6895 (90.0)† | 14,750 (93.2) | 14,652 (92.5)†‡ | 648 (93.1) | 652 (93.7)†‡ | 390 (91.1) | 389 (90.9)† |
| Annual prescriptions per patient [mean (SD)] | 23.2 (25.6) | 25.7 (27.1)* | 23.6 (26.0) | 25.9 (27.4)* | 33.6 (31.6) | 35.0 (33.2)*† | 41.0 (36.4) | 46.4 (39.1)*†‡ | 40.1 (34.1) | 48.9 (38.2)*†‡ | 33.0 (30.9) | 39.8 (34.1)*†‡ |
| % change from preindex to postindex period | 10.6 | 9.9 | 4.0 | 13.2 | 20.6 | 21.9 | ||||||
§NAFLD/NASH study cohort comprises overall NAFLD/NASH patients until progression to a more severe stage, at which follow-up is censored.
AdvLD indicates advanced liver diseases; CC, compensated cirrhosis; DCC, decompensated cirrhosis; HCC, hepatocellular carcinoma; LT, liver transplantation; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis.
*P<0.05 for comparison of preindex versus postindex period.
†P<0.05 for comparison of CC, DCC, LT, or HCC cohort versus NAFLD/NASH without AdvLD cohort (postindex).
‡P<0.05 for comparison of DCC, LT, or HCC cohort versus CC cohort (postindex).