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. 2021 Sep 24;12:748574. doi: 10.3389/fphys.2021.748574

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Copyright © 2021 Yamada, Yoshizaki, Ishikawa, Saito, Chiba, Fukumoto, Hino, Hoshikawa, Chiba, Nakamura, Iwamoto and Fukumoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tooth phenotypes in Cx43-deficient mice. (A) Hematoxylin staining of upper first molars in wt and Cx43^−/− mice, and high-magnification images and scheme of dental epithelial cells in newborn wt and Cx43^−/− mice. st, stellate reticulum; si, stratum intermedium; iee, inner enamel epithelium; od, odontoblast; dp, dental papilla. (B) Relative numbers of each cell types in wt, Cx43^+/−, and Cx43^−/− mice. n−5, ^**p<0.01. (C) Expression of Cx43, enamel matrix proteins, and BMPs in first molar tooth germs in P3 WT and Cx43^−/− mice. Ambn, ameloblastin; Enam, enamelin; Amel, amelogenin. n−4, ^**p<0.01. (D) Localization of Cx43 (red) and Ambn (green) in wt and Cx43^−/− molars.