Table 1.
Longest and shortest average single-telomere lengths of end telomeres (terminal) and telomere loss.
| Cell line used in telomere characterization | Longest single telomere lengtha | Shortest single telomere lengtha | Overall Average Telomere Length | Total Telomere loss | Telomeres <500bp (% total) |
|---|---|---|---|---|---|
| IMR90_PD17 | (1p) 13.2 ± 5.4 (24) | (9p) 3.6 ± 3.0 (34) | 7.2 ± 1.7 (802) | 0 | 0(0%) |
| IMR90_PD17 | (3p) 8.9 ± 4.4 (31) | (3q) 3.9 ± 3.0 (23) | |||
| IMR90_PD17 | (8p) 8.9 ± 6.8 (33) | (16q1) 5.3 ± 4.5 (14) | |||
| IMR90_PD45 | (2q1) 9.3 ± 4.5 (13) | (6p2) 1.6 ± 1.4 (20) | 4.5 ± 1.7 (742) | 0 | 22(3.0 %) |
| IMR90_PD45 | (2q2) 7.4 ± 6.1 (16) | (8p) 2.1 ± 1.7 (9) | |||
| IMR90_PD45 | (1p) 6.7 ± 4.5 (10) | (6p1) 2.1 ± 2.0 (14) | |||
| IMR90_Senescence | (2q1) 5.5 ± 4.8(24) | (8p) 2.4 ± 2.1 (31) | 4.0 ± 1.0(851) | 0 | 74(8.7 %) |
| IMR90_Senescence | (20p) 5.4 ± 3.7 (23) | (8q) 2.6 ± 2.5(31) | |||
| IMR90_Senescence | (7q) 5.1 ± 3.0(30) | (19p) 3.0 ± 2.1 (31) | |||
| UMUC3 | (10q) 6.0 ± 3.4(23) | (8q) 1.0 ± 0.5(31) | 3.1 ± 1.3 (871) | 0 | 65(7.4 %) |
| UMUC3 | (12q) 5.8 ± 3.8(31) | (6p2) 1.2 ± 0.8 (12) | |||
| UMUC3 | (3p) 5.4 ± 3.5 (31) | (20p) 1.6 ± 1.1 (23) | |||
| LNCaP | (5q1) 4.5 ± 1.9(27) | (20p) 1.8 ± 0.9 (12) | 3.0 ± 0.7 (959) | 0 | 20(2.1 %) |
| LNCaP | (6p1) 4.2 ± 2.0 (10) | (10q) 2.0 ± 0.8(26) | |||
| LNCaP | (5q2) 4.1 ± 1.8(22) | (8q) 2.2 ± 1.6(31) | |||
| U20S | (20p)7.8 ± 12.2 (20) | (18q)0.5 ± 1.2 (5) | 3.1 ± 3.5 (906) b | 165(57,108) c | 158(6593)(17 %) d |
| U20S | (6q)7.8 ± 7.9 (21) | (8q)1.8 ± 3.5 (23) | |||
| U20S | (19p)7.0 ± 8.1 (29) | (2p)2.1 ± 2.5 (12) | |||
| SK-MEL-2 | (19q)5.1 ± 5.4 (31) | (XqYq)1.2 ± 1.9 (16) | 3.4 ± 3.5 (862) b | 43(38,5) c | 92(85,7) (11 %) d |
| SK-MEL-2 | (12q)4.9 ± 4.3 (31) | (9q)1.3 ± 2.0 (7) | |||
| SK-MEL-2 | (15q)4.8 ± 3.5 (30) | (16q)1.3 ± 1.1 (20) | |||
| Saos-2 | (6q)8.9 ± 10.0 (27) | (8q)1.1 ± 0.7 (15) | 4.3 ± 4.2 (862) b | 49(46,3) c | 53(42,10) (7.8 %) d |
| Saos-2 | (6p)7.7 ± 7.6 (10) | (17q)1.6 ± 1.9 (10) | |||
| Saos-2 | (3p)7.5 ± 5.5 (30) | (7q)1.9 ± 1.4 (27) |
Average Single Telomere Lengths in kb: Mean ± Std (number of telomeres).
End telomere loss: Events where some molecules in a specific sample have demonstrated lack of telomere-like signal at the end of chromosome. Some of these events manifest as additional internal telomere like sequences with blight label while some did not have any ITS.
ITS loss: Events where ITS signal loss is observed.
Total Telomere loss: This is defined as the total number of molecules where either loss of end telomeres signal is observed or loss of ITS signal is observed.
End telomere length.
Includes both ends and recombined ends.
Total telomere loss (end telomere loss, ITS loss).
Total telomere less than 500bp (end telomere<500bp, ITS<500bp) (% of total telomeres).