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Risk of herpes zoster with biologics compared with non-biological systemic therapies and MTX. Compared with non-biological systemic therapies, the risks of HZ increased with the use of biologics (OR: 1.32; 95% CI: 1.02–1.71; I2 = 0%); when compared with MTX, such a risk was not observed. CI = confidence interval, MTX = methotrexate, OR = odds ratio.
