Fig. 7.

Gene expression comparison between ReNcell VM and ReNcell CX. (A) Volcano plot depicting differentially expressed genes between ReNcell VM and ReNcell CX from GSE89623 (n = 2 for both groups; culture time is 2 weeks), discriminated based on p-value and log2(foldchange) at an level of 0.05 and FDR adjusted p-value (≤ 0.1). Black dots correspond to individual genes whose expression differences were significant based on both p and logFC value, while red dots denote not significantly different genes. (B) Volcano plot of selected genes specifically associated with nuclear mechanotransduction show a majority number of such genes are differentially expressed between the two cell types. (C) Absolute levels of various genes linked to mechanotransduction in ReNcell VM. Data was denoted as counts per million (CPM), and from two separate cell lines of ReNcell VM which were averaged and plotted. Note: data shown here may not be comprehensive in depicting all known genes contributing to mechanotransduction.