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. Author manuscript; available in PMC: 2021 Oct 8.
Published in final edited form as: Cell Rep. 2021 Sep 14;36(11):109701. doi: 10.1016/j.celrep.2021.109701

Figure 1. Extracellular citrate uptake is tissue specific.

Figure 1.

(A) Plasma concentration of TCA intermediates in humans (n = 8).

(B) Citrate concentration in cell culture medias (n = 3) and human plasma (n = 8) same as in (A).

(C) SLC13A5 mRNA expression in human tissues, from (Uhlén et al., 2015).

(D) SLC13A5 mRNA expression in cancer cells grown in normoxia relative to Huh7s (n = 3).

(E) Slc13a5 mRNA expression in primary rat neuron and astrocyte cells in normoxia relative to neurons (n = 3).

(F) Net citrate uptake flux in cancer cell lines over 48 h (n = 3).

Cit, citrate; α-KG, α-ketoglutarate; Suc, succinate; Fum, fumarate; Mal, malate. All data are presented as means ± SD. All data are representative of three sample replicates.