Table 4.
Arachidonate-5-lipoxygenase (A5-LOX) and xanthine oxidase enzyme inhibitory activities and oxidative burst inhibitory activities of ethanolic and methanolic extracts of Sri Lankan finger millet varieties.
| Extract/standard | A5-LOX inhibitory activity | Xanthine oxidase inhibitory activity | Oxidative burst inhibitory activity | |
|---|---|---|---|---|
| Whole human blood | Isolated polymorphonuclear neutrophils | |||
| Ravi E | 627.25 ± 7.35b | 868.32 ± 6.64a | 52.7 ± 1.3b | 1.56 ± 0.14b |
| Rawana E | 684.10 ± 7.52a | 892.69 ± 5.61a | 59.3 ± 0.9a | 1.70 ± 0.12b |
| Oshadha E | 638.70 ± 8.98b | 832.57 ± 3.84b | 59.1 ± 0.8a | 1.35 ± 0.19b |
| Ravi M | 587.97 ± 4.76c | 781.95 ± 2.62cd | 26.9 ± 0.6c | 0.29 ± 0.02c |
| Rawana M | 590.08 ± 6.53c | 797.20 ± 5.90c | 27.4 ± 0.3c | 0.47 ± 0.05c |
| Oshadha M | 484.42 ± 5.54d | 764.34 ± 8.47d | 27.7 ± 1.0c | 0.44 ± 0.03c |
| Baicalein | 1.76 ± 0.15e | NA | NA | NA |
| Allopurinol | NA | 108 ± 0.62e | NA | NA |
| Ibuprofen | NA | NA | 11.18 ± 1.87d | 2.47 ± 0.59a |
Results are presented as mean ± SE (n = 6). All inhibitory activities are given as IC50 values (μg/ml). Within a column, mean values superscripted with different letters are significantly different at P < 0.05 while mean values superscripted with the same letter are not significantly different at P ≥ 0.05. NA: not applicable; E: ethanolic extract; M: methanolic extract.