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Effects of exercise-induced ROS on the signaling pathway in the skeletal muscle. Exercise-induced ROS can activate MAPK and Akt signaling pathways. Nrf2 dissociates from its cytoplasmic inhibitor Keap1 then translocates to the nucleus and combines with ARE to contribute to some downstream antioxidant gene transactivation, such as the oxidases, COX, SOD, GPX, and GSH.
