Table 2. Showing platelet response towards Helicobacter pylori eradication therapy.

Authors Name	Year of Study	Country of Study	Prevalence of H-pylori Infection	Detection of H-pylori Infection	Treatment Given	Platelets Response
Maghbool et al. [41]	2009	Iran	Out of thirty diagnosed cases of ITP, five were found positive for H-pylori infection, with a prevalence of 17%.	All patients with positive stool antigen test (ELISA) for H-pylori infection.	Triple Therapy (omeprazole 1 mg/kg/day, metronidazole 30 mg/kg/day, amoxicillin 60 mg/kg/day) for 14 days and follow-up for one year.	All the patients diagnosed with H-pylori infection (n = 5) showed improvement in platelet count after triple therapy with a 100% response rate (5/5).
Jaing et al. [46]	2003	Taiwan	Out of twenty-two diagnosed cases of ITP, nine were found positive for H-pylori infection, with a prevalence of 41%.	All patients with positive stool antigen test (ELISA) for H-pylori infection.	Triple therapy (amoxicillin 1000 mg twice daily, clarithromycin 500 mg twice daily, lansoprazole 60 mg once per day) for 7 days.	Of all the patients diagnosed with H-pylori infection (n = 9) who received eradication therapy, only 5 patients showed a rise in platelet count with a response rate of 55.5%, and platelets remain elevated throughout the follow-up period.
Ando et al. [47]	2003	Japan	Out of 61 diagnosed cases of ITP, 50 patients were found positive, with a prevalence of 83%.	H-pylori detection was done through a urea breath test (UBT).	Triple therapy (amoxicillin 1000 mg twice daily, clarithromycin 500mg twice daily, pantoprazole 40 mg once per day) for 7-days.	Out of 50 H-pylori positive patients, only 29 patients received H-pylori eradication therapy, and 27 patients with a response rate of 93% showed a rise in platelet count with UBT being negative. Similarly, 16 (55.1%) out of 29 patients showed a major or minor response.
Hashino et al. [48]	2003	Japan	Out of 22 diagnosed cases of ITP, 14 were found positive for H-pylori infection with a prevalence rate of 64%.	Histological and cultural examination of a biopsy obtained from gastric mucosa through GI endoscopy.	The patient was given triple therapy (omeprazole 40mg once a day, amoxicillin 1000 mg twice daily, clarithromycin 500 mg twice daily) for 7 days.	Out of 14 H-pylori positive patients, only 13 patients received H-pylori eradication therapy, and only 5 patients showed recovery in platelet count (more than 100 × 109/L) with a response rate of 38.4%.
Tag HS et al. [49]	2010	Korea	Out of 25 diagnosed cases of ITP, 23 patients were found positive for H-pylori infection with a prevalence rate of 92%.	H-pylori detection was done through UBT, serum H-pylori antibodies, and rapid urease test (CLO test).	The patient was given triple therapy (omeprazole 40mg once a day, amoxicillin 1000 mg twice daily, clarithromycin 500 mg twice daily) for 14 days.	Out of 23 diagnosed cases of H-pylori infection and received H-pylori eradication therapy, only 17 patients were showing response in terms of an increase in platelet counts with a response rate of 73.9%.
Payandeh et al. [50].	2012	Iran	Out of 52 diagnosed cases of ITP, only 35 patients were found positive for H-pylori infection, with a prevalence of 67.3%.	H-pylori detection was done through UBT and serum H-pylori antibodies.	Triple therapy (amoxicillin 1000 mg twice daily, clarithromycin 500 mg twice daily, pantoprazole 40 mg once per day) for 14-days.	Out of 35 diagnosed cases of H-pylori infection, only 26 patients received H-pylori eradication therapy, but only 15 patients showed a rise in platelet count (more than 100 × 109/L) with a response rate of just 57.7%.
Lee et al. [51]	2020	Korea	Out of 138 diagnosed patients of 75 were found positive for H-pylori infection with a prevalence of 54.3%.	H-pylori detection was done through UBT, CLO test, Wright Giemsa stain, and H-pylori antibodies.	Triple therapy (PPI twice a day, amoxicillin 1000 mg twice daily, clarithromycin 500 mg twice daily) for 7–21 days. And Quadruple therapy (PPI twice a day, bismuth 120 mg four times a day, metronidazole 500 mg three times a day, tetracycline 500 mg four times a day) for 14 days in patients unresponsive to triple therapy.	The complete response rate in the eradication group at the end of two months was 38.5%, and at the end of the sixth month, it was just 36.8%. However, patients who achieved CR at 2 months of therapy showed a sustained response in 77.8% of the patients.

Note: H-pylori: Helicobacter pylori, UBT: Urea breath test, ITP: Immune thrombocytopenic purpura, EGD: Esophagogastroduodenoscopy, ELISA: Enzyme-linked immunosorbent assay. HPPE group: H-pylori positive eradication group.