| Song et al. [54]
|
2008 |
Korea |
A total of 34 patients with ITP and H-pylori infection identified based on CLO, UBT, and IgG and were given EA and EL were involved in the study. |
Triple therapy (Amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, esomeprazole 40 mg twice daily) for 14 days. |
CR was observed in just 4 patients. |
PR was observed in 10 patients. |
The remaining 20 patients were not showing any response. |
| Aljarad et al. [16]. |
2018 |
Syria |
Out of 50 diagnosed cases of ITP, 36 were diagnosed with H-pylori infection based on histological examination through biopsies, UBT, and anti- H-pylori antibodies. |
Triple therapy (omeprazole 40 mg once per day, amoxicillin 1000 mg twice daily, clarithromycin 500 mg twice daily) for 14 days. |
CR was observed in 10 patients. |
PR was observed in 18 patients. |
The remaining 22 patients either given eradicated therapy or not were showing no response platelets count. |
| Sheema et al. [17]
|
2017 |
Pakistan |
Out of 85 cases of ITP only 34 patients were found positive for H-pylori infection on the basis of stool antigen test through the Rapid Immunochromatography. |
Triple therapy (Amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, proton pump inhibitor 40 mg twice daily) for 14 days. |
CR was observed in 19 patients. |
PR response was observed in 10 patients. |
The remaining 5 patients who were given eradication therapy didn't showed any response |
| Tag HS et al. [49]. |
2010 |
Korea |
Out of 25 diagnosed cases of ITP 23 were diagnosed positive for H-pylori infection based on UBT, rapid urease test (CLO test) by endoscopic biopsy. |
Triple therapy (Amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, proton pump inhibitor 40 mg twice daily) for 7 or 14 days. |
CR was observed in 11 patients. |
PR was observed in 6 patients. |
The remaining 8 patients who were given eradication therapy didn't showed any response. |
| Payandeh et al. [50]. |
2012 |
Iran |
Out of 52 diagnosed cases of ITP, only 35 patients were found positive for H-pylori infection based on UBT and antibodies tests, but 3 patients with autoimmune disease, 2 with HBV and 1 with HCV infection were excluded and only 26 were assessed for response. |
Triple therapy (Amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, proton pump inhibitor 40 mg twice daily) for 14 days. |
CR was observed in 15 patients. |
None of the treated patients showed partial response. |
The remaining 11 patients who were given eradication therapy didn't showed any response. |
| Sato et al. [55]
|
2004 |
Japan |
Out of 53 diagnosed cases of ITP only 39 were found positive for H-pylori infection based on UBT and only 32 patients received eradication therapy. |
Triple therapy (Amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, proton pump inhibitor 40 mg twice daily) for 14 days. |
CR was observed in 10 patients. |
PR was observed in 5 patients. |
The remaining 17 patients who received eradication therapy did not showed any response. |
