Table 3.
Description of the primary estimand
| Question | Trials (n = 50)—no. (%) |
|---|---|
| Used term “estimand” | 0 (0%) |
| Cited ICH E9(R1) Addendum | 0 (0%) |
| Estimand attributes | |
| Population | |
| Stated | 0 (0%) |
| Inferable | 32 (64%) |
| Not inferable | 18 (36%) |
| Treatment condition(s) | |
| Stated | 0 (0%) |
| Inferable | 40 (80%) |
| Not inferable | 10 (20%) |
| Outcome | |
| Stated | 50 (100%) |
| Inferable | 0 (0%) |
| Not inferable | 0 (0%) |
| Population-level summary measure | |
| Stated | 0 (0%) |
| Inferable | 33 (66%) |
| Not inferable | 17 (34%) |
| Handling of intercurrent event(s) | |
| Stated | 0 (0%) |
| Inferable | 20 (40%) |
| Not inferable | 30 (60%) |
| Overall estimand | |
| Stated | 0 (0%) |
| Inferable | 13 (26%) |
| Not inferable | 37 (74%) |
| Number of attributes not inferable | |
| 0 | 13 (26%) |
| 1 | 14 (28%) |
| 2 | 9 (18%) |
| 3 | 13 (26%) |
| 4 | 1 (2%) |
| 5 | 0 (0%) |