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. 2021 Oct 8;28(10):835–846. doi: 10.1038/s41594-021-00666-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (a) Stick diagram of PPP1R15A and the corresponding 2Fo-Fc map, contoured at 1.0σ within 2.0 Å of PPP1R15A atoms. (b) Ribbon diagram of F-actin (PDB 3J8A, tropomyosin omitted) in grey with protomers numbered. The PPP1R15A/G-actin complex (in red and green respectively, with DNase I removed) has been aligned with protomer 1. Actin D-loops are shown in blue and the clash between D-loop insertion and PPP1R15A binding to G-actin is indicated by the arrow. (c) The PPP1R15A/G-actin complex with actin domains numbered and a docked molecule of cytochalasin D (from PDB 3EKS), clashing with the C-terminal helix of PPP1R15A.