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. 2021 Aug 21;142(5):841–857. doi: 10.1007/s00401-021-02354-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — t-distributed stochastic neighbor embedding (tSNE) clustering of DNA methylation patterns of 60 NET-PATZ1 tumors alongside 942 in-house reference samples representing 15 other low- and high-grade glial and glioneuronal tumor types, using the 10,000 most variably methylated probes. NET-PATZ1 forms a distinct ‘island’. CNS_NB_FOXR2 CNS neuroblastoma with FOXR2 activation; DNET dysembryoplastic neuroepithelial tumor; EFT_CIC CNS ewing sarcoma family tumor with CIC alteration; GBM_G34 glioblastoma, H3.3 G34 mutant; GBM_MES glioblastoma, subclass mesenchymal; GBM_pedMYCN pediatric-type glioblastoma, subclass MYCN; GBM_pedRTKI pediatric-type glioblastoma, subclass RTKI; GBM_pedRTKII pediatric-type glioblastoma, subclass RTK II; GG ganglioglioma; HGNET_BCOR CNS high-grade neuroepithelial tumor with BCOR alteration; HGNET_MN1 CNS high-grade neuroepithelial tumor with MN1 alteration; NET_PATZ1 neuroepithelial tumor with PATZ1 fusion; PA_CORT hemispheric pilocytic astrocytoma; PXA pleomorphic xanthoastrocytoma; SEGA subependymal giant cell astrocytoma; ST_EPN_RELA supratentorial ependymoma, RELA fused