Fig. 5.

NF-κB not only has neuroprotective effect, but also has nerve injury effect. Because of the diversity of NF-κB complex and its activator, the diversity of target genes and the specificity of cells, it can induce genes encoding death or survival protein and has the effect of promoting apoptosis or anti-apoptosis. As a result, NF-κB not only has neuroprotective effect, but also has nerve injury effect and participates in the degeneration or other adverse changes of central nervous system in the process of central fatigue