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. 2021 Sep 8;142(5):873–886. doi: 10.1007/s00401-021-02351-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pediatric meningiomas are aggressive tumors with uncommon histological features. a Examples of histological subtypes more frequent among pediatric meningiomas than in adult tumors. a Clear cell meningioma WHO grade II. b Chordoid meningioma WHO grade II. c Rhabdoid meningioma WHO grade III. d Atypical meningioma WHO grade II with brain invasion. Distribution by WHO grade (b) and histological variants (c). d, e Kaplan–Meier curves showing clinical characteristics of 17 pediatric meningiomas with follow-up data available. f Proliferation activity as determined by Ki-67 immunostaining within different WHO grades. g Recurrence-free survival according to the tumor localization (skull base or convexity)