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. 2021 Sep 8;142(5):873–886. doi: 10.1007/s00401-021-02351-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Methylation profile of 37 pediatric meningiomas. a Unsupervised hierarchical clustering reveals three subgroups (1, 2A, 2B). Arrows indicate tumors not classified as meningioma in the meningioma classifier for adult tumors. Radiation-induced pediatric meningiomas are marked by (*). b Relation between histological variant and methylation subgroup. Frequency of NF2-LOH (c) and clinical diagnosis of NF2 (d) among the three subgroups. e Frequency of LOH at chromosome 11 among the three subgroups. Note that c-e display data for 35 cases after exclusion of two cases (arrows) which were not classified as meningioma using the meningioma classifier [31]