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. 2021 Aug 5;142(5):827–839. doi: 10.1007/s00401-021-02356-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Illustration of the PLAGL1 fusion genes and transcriptional profiling of tumors samples in the novel group (NET_PLAGL1). Visualization of the PLAGL1 fusion genes detected by RNA sequencing for three selected samples. EWSR1:PLAGL1 fusion in case #1, in which exons 1–9 of EWSR1, as the 5’ partner, are fused to exon 5 of PLAGL1 (a), PLAGL1:FOXO1 fusion in case #18, in which exons 1–5 of PLAGL1 are fused to exons 2–3 of FOXO1 as the 3’ partner (b), and PLAGL1:EP300 fusion in case #19, in which exons 1–5 of PLAGL1 are fused to exons 15–31 of EP300 as the 3’ partner (c), conserving the zinc finger structure (C2H2 type) as part of the fusion products. Differences in gene expression profiles between samples in the novel group and ZFTA:RELA-fused ependymomas. Normalized transcript counts from samples in the novel group and ZFTA:RELA-fused ependymomas clustered by Pearson’s correlation coefficient (d) and principal component analysis (e). Volcano plot depicting genes differentially expressed between samples in the novel group versus ZFTA:RELA-fused ependymomas (f). PLAGL1 (g), H19 (h), IGF2 (i), ZFTA (j), and RELA (k) expression in the novel group (n = 20) compared to ZFTA:RELA-fused ependymoma samples (n = 14)