Table 1.

Summary of selected analgesics interactions

NSAIDs	SSRI, corticosteroids	Increased bleeding risk (especially in the gastrointestinal tract)
	In combination with ACE inhibitors risk of renal failure	Risk of renal failure
	With antidepressants, anticonvulsants, antipsychotics and opioids	Increased electrolyte imbalance like hyponatremia
Paracetamol	With 5‑HT3 antagonists (e.g. ondansetron or tropisetron)	Reduction of analgesic efficacy
Antidepressants	–	Increased incidence of arrhythmia in patients with cardiac impairments
Gabapentin	With antacids	Reduced resorption (at least 2‑h intervals between doses)
Pregabalin	With oxycodone	Possible impairment of cognitive and gross motor skills

NSAID nonsteroidal anti-inflammatory drugs, SSRI Selective Serotonin Reuptake Inhibitors