Table 4.

Hazard ratios for the association of diastolic blood pressure variability with the primary outcome and major CHD, in those with CVD history at baseline, those with CVD history and low baseline blood pressure (<120 mmHg SBP & <70 mmHg DBP), and those without CVD history at baseline in each category.

	Model-1 Age adjustment		Model-2 Multivariate adjustment		Model-3 Model 2 + cumulative mean BP
Primary CVD outcome
With CVD history
All (n=479)	1.20 (1.12–1.28)	<0.0001	1.20 (1.11–1.30)	<0.0001	1.21 (1.12–1.30)	<0.0001
Low BP (n=73)	1.33 (1.15–1.53)	0.0001	1.33 (1.15–1.53)	0.0001	1.29 (1.13–1.48)	0.0002
No CVD history
All (n = 400)	1.07 (0.98–1.18)	0.10	1.09 (0.98–1.20)	0.11	1.09 (0.98–1.20)	0.10
Low BP (n=36)	1.22 (0.93–1.62)	0.14	1.25 (0.95–1.64)	0.12	1.19 (0.90–1.57)	0.22
Major CHD
With CVD history
All (n=572)	1.22 (1.14–1.29)	<0.0001	1.22 (1.14–1.30)	<0.0001	1.22 (1.13–1.31)	<0.0001
Low BP (n=86)	1.42 (1.26–1.59)	<0.0001	1.40 (1.22–1.60)	<0.0001	1.40 (1.22–1.61)	<0.0001
No CVD history
All (n=413)	1.17 (1.07–1.27)	0.0004	1.14 (1.03–1.25)	0.01	1.14 (1.03–1.25)	0.01
Low BP (n=37)	1.06 (0.79–1.43)	0.69	1.04 (0.77–1.40)	0.79	1.02 (0.75–1.38)	0.89

Hazard ratios (HR), (95% confidence interval (95% CI)), and p-values estimated by Cox proportional hazards model for coefficient of variation of DBP. Blood pressure variables were adjusted for age (Model 1), baseline factors that differed significantly between those who did and did not develop each event (Model 2) and additionally for cumulative mean of blood pressure excluding the baseline BP. P-values <0.05 (bold font) are considered significant.