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. Author manuscript; available in PMC: 2022 Oct 7.
Published in final edited form as: Structure. 2021 May 20;29(10):1094–1104.e4. doi: 10.1016/j.str.2021.05.003

Figure 2. Overall structure of SpNatC reveals intimate interactions among all subunits.

Figure 2.

(a) Naa30 (bright orange), Naa38 (dark purple) and Naa35 (lime green) are shown in transparent surface and cartoon, with the boxed area labeled.

(b) The CoA-MLGP bisubstrate conjugate and inositol hexaphosphate (IP6) are shown in sticks and colored in blue.

(c) Zoom-in view of the first sub-interface between Naa38 and Naa35. Hydrogen bonds are indicated by dashed black lines. For simplicity, only some of the hydrophobic interactions are shown.

(d) Zoom-in view of the second sub-interface between Naa38 and Naa35.

(e) Zoom-in view of the third sub-interface between Naa38 and Naa35, which also involves some residues from Naa30 (light orange).

(f) Zoom-in view of the interface between Naa35 and Naa30 α1-α2 segment.

(g) Zoom-in view of the interface between Naa35 and Naa30 β6-β7 segment.

(h) Zoom-in view depicting key residues involved in interactions with IP6. The lower left corner shows the fit of the IP6 molecule in the EM density map. The contour level is 5.0 sigma.