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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Mol Neurobiol. 2021 Jun 26;58(10):4787–4801. doi: 10.1007/s12035-021-02461-3

Fig. 4.

Fig. 4

GluD1 ablation from PV neurons reduces the inhibitory neurotransmission in the NAc core. A. GluD1 was found to colocalize to PV neurons in the NAc core. Immunohistochemical analysis for GluD1 (green) and PV (red) indicates that GluD1 localizes on dendrites and soma of PV neurons in the NAc core. B. No change in the number of PV neurons in the NAc upon ablation of GluD1 from PV neurons (N = 3 per genotype). C. Modest reduction in the amplitude of mIPSC but no change in frequency in mice with GluD1 ablation from PV neurons. Reduction in the amplitude of mIPSCs in PV-GluD1 KO (WT: 14.38 ± 1.012 pA vs. PV-GluD1 KO: 11.68 ± 0.6857 pA, p = 0.0337, Unpaired t-test; N = 14–15 from 3 to 4 animals per genotype)